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Kolliphor EL, formerly known as Cremophor EL, is the registered trademark of BASF Corp. for its version of polyethoxylated castor oil. It is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil. The resulting product is a mixture (CAS number 61791-12-6): the major component is the material in which the hydroxyl groups of the castor oil triglyceride have ethoxylated with ethylene oxide to form polyethylene glycol ethers. Minor components are the polyethyelene glycol esters of ricinoleic acid, polyethyelene glycols and polyethyelene glycol ethers of glycerol.〔(【引用サイトリンク】url=http://www.pharma-ingredients.basf.com/Statements/Technical%20Informations/EN/Pharma%20Solutions/EMP%20030711e_Cremophor%20EL.pdf )〕 Cremophor EL is a synthetic, nonionic surfactant. Its utility comes from its ability to stabilize emulsions of nonpolar materials in aqueous systems. Kolliphor EL is an excipient or additive in drugs. Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or additives such as Kolliphor EL.〔 See page 1/49, Methods and Materials.〕 ==Uses== * Miconazole, anti-fungal * Paclitaxel, anti-cancer * Docetaxel, anti-cancer * Aci-Jel (acetic acid / oxyquinoline / ricinoleic acid - vaginal) * Sandimmune (cyclosporine injection, USP) * Nelfinavir mesylate, HIV protease inhibitor * Propofol, intravenous anaesthetic agent, originally presented in Kolliphor EL for trials; now presented in a lipid emulsion * Diazepam injection; superseded by lipid emulsion alternative (Diazemuls) * Vitamin K injection * Ixabepilone, anti-cancer 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Kolliphor EL」の詳細全文を読む スポンサード リンク
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